A forward genetic screen is a biomedical technique that aims to discover the genes behind an observed phenotype. It is a technique that can be used to discover genes that control neuronal development, for example by creating mutants that interfer with the development of neurons and...

Green fluorescent protein, or GFP, was originally used in C. elegans by Dr Martin Chalfie. Dr Chalfie worked with the scientist Sidney Brenner - the first scientist to champion the use of C. elegans as a model organism. It is a protein with fluorescent capabilities found in the jellyfish Aequorea...

Nomarski interference microscopy, also known as differential interference contrast (DIC) microscopy, is the visual method used for finding the complete lineage of every neuronal cell in the nematode C. elegans. An extremely useful tool for viewing the constituents in transparent specimens. Light...

The starting point for RNA interference was discovered by Guo and Kemphues in 1995 whilst attempting to use antisense RNA to block gene expression in the maternal germ cell line. During their experiments, they came accross the suprising development that both antisense and sense RNA could silence...